Potential prophylactic impact of B vitamins against zinc oxide bulk and its nanoparticles induced kidney damage

The protective effect of B vitamins combination against zinc oxid bulk (ZnO-bulk) and its nanparticles (ZnO-NPs) toxicity -induced kidney damage in rats was investigated. ZnObulk or its NPs were administered orally (500 mg /kg body weight) for 10 consecutive days. The results revealed that oral co-ingestion of of B vitamins combination (250 mg B3, 60 mg B6 and 0.6 mg B12 / Kg body weight) daily for 3 weeks to rats intoxicated by either ZnObulk or its NPs markedly ameliorated increases in serum markers of kidney function, including uric acid and creatinine. Also the used vitamins in combination down-modulated ZnO caused dramatic increases in serum proinflammatory biomarkers including, tumor necrosis factorα (TNF-α), and C-reactive protein (CRP) as well as in serum vascular endothelial growth factor (VEGF) (angiogenic factor) in intoxicated rats compared with intoxicated untreated ones. In addition, the result showed that B vitamins effectively ameliorated the increased malondialdehyde (MDA, a major product of lipid peroxidation), the decrease in antioxidant enzyme, glutathione peroxidase (GPx), oxidative deoxyribonucleic acid (DNA) damage and the increase in the apoptosis marker caspase 3 in kidneys of intoxicated rats with either ZnObulk or its NPs compared with intoxicated untreated.In conclusion, prophylactic treatment with the current used B vitamins in combination may be beneficial in protecting kidney tissue from the toxic impact of ZnObulk or its NPs. [Jehad M. Yousef. Potential prophylactic impact of B vitamins against zinc oxide bulk and its nanoparticles induced kidney damage. Life Sci J 2014;11(8):729-738]. (ISSN:1097-8135). http://www.lifesciencesite.com. 108